Interactions médicamenteuses
Alogliptin-pioglitazone + Daprodustat
Gravité: Modérée
Alogliptin-pioglitazone and Daprodustat: moderate interaction.
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Résumé
Pioglitazone is a weak CYP2C8 inhibitor, whereas daprodustat is a CYP2C8 substrate whose exposure rises with strong inhibitors such as gemfibrozil. A modest increase in daprodustat levels is possible, which could increase hemoglobin and thrombotic risk.
Ce que signifie cette interaction, en termes simples
Alogliptin-pioglitazone and Daprodustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alogliptin-pioglitazone belongs to Endocrine; Daprodustat belongs to Endocrine.
Pourquoi elle survient
Inhibition of CYP2C8-mediated daprodustat metabolism.
Conduite à tenir
Monitor hemoglobin and adjust the daprodustat dose accordingly when pioglitazone is started or stopped.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Alogliptin-pioglitazone
Autres interactions de Daprodustat
- Daprodustat + Gemfibrozil Contre-indiquée
- Abiraterone + Daprodustat Modérée
- Carbamazepine + Daprodustat Modérée
- Clopidogrel + Daprodustat Modérée
- Daprodustat + Deferasirox Modérée
- Daprodustat + Hydrochlorothiazide-irbesartan Modérée
Questions fréquentes
Can I take Alogliptin-pioglitazone with Daprodustat?
MediHelp rates the interaction as moderate. Alogliptin-pioglitazone and Daprodustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pioglitazone is a weak CYP2C8 inhibitor, whereas daprodustat is a CYP2C8 substrate whose exposure rises with strong inhibitors such as gemfibrozil. A modest increase in daprodustat levels is possible, which could increase hemoglobin and thrombotic risk.
How serious is the interaction between Alogliptin-pioglitazone and Daprodustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and adjust the daprodustat dose accordingly when pioglitazone is started or stopped.
What other medicines interact with Alogliptin-pioglitazone?
MediHelp also lists interactions of Alogliptin-pioglitazone with, for example, Gemfibrozil, Insulin aspart, Insulin degludec. The full list is on the Alogliptin-pioglitazone page.
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