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Interactions médicamenteuses

Daprodustat + Gemfibrozil

Gravité: Contre-indiquée

Daprodustat and Gemfibrozil: contraindicated interaction.

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Résumé

Gemfibrozil and its glucuronide strongly inhibit CYP2C8, the main enzyme clearing daprodustat, causing a marked rise in daprodustat exposure. This increases the risk of excessive erythropoiesis and thrombotic events, and labeling contraindicates the combination.

Ce que signifie cette interaction, en termes simples

Daprodustat and Gemfibrozil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Daprodustat belongs to Endocrine; Gemfibrozil belongs to Cardiovascular.

Niveau de preuve: High

Pourquoi elle survient

Strong CYP2C8 inhibition by gemfibrozil and its glucuronide metabolite reduces daprodustat clearance.

Conduite à tenir

Do not coadminister; use a different lipid-lowering agent such as a statin or fenofibrate. Monitor hemoglobin if exposure occurs.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Daprodustat with Gemfibrozil?

MediHelp rates the interaction as contraindicated. Daprodustat and Gemfibrozil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Gemfibrozil and its glucuronide strongly inhibit CYP2C8, the main enzyme clearing daprodustat, causing a marked rise in daprodustat exposure. This increases the risk of excessive erythropoiesis and thrombotic events, and labeling contraindicates the combination.

How serious is the interaction between Daprodustat and Gemfibrozil?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use a different lipid-lowering agent such as a statin or fenofibrate. Monitor hemoglobin if exposure occurs.

What other medicines interact with Gemfibrozil?

MediHelp also lists interactions of Gemfibrozil with, for example, Elagolix, Mavacamten, Metformin-repaglinide. The full list is on the Gemfibrozil page.

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