Interactions médicamenteuses
Daprodustat + Deferasirox
Gravité: Modérée
Daprodustat and Deferasirox: moderate interaction.
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Résumé
Deferasirox inhibits CYP2C8 to a moderate degree, and daprodustat is cleared mainly by CYP2C8. Exposure to daprodustat can rise, with a greater erythropoietic response and the risk of excessive hemoglobin increases.
Ce que signifie cette interaction, en termes simples
Daprodustat and Deferasirox can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daprodustat belongs to Endocrine; Deferasirox belongs to Miscellaneous.
Pourquoi elle survient
Deferasirox inhibits CYP2C8-mediated metabolism of daprodustat.
Conduite à tenir
Halve the daprodustat starting dose when it is started with deferasirox, unless the starting dose is already 1 mg. Monitor hemoglobin and adjust the dose when deferasirox is started or stopped.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Deferasirox
- Acetylsalicylic acid + Deferasirox Majeure
- Alosetron + Deferasirox Majeure
- Aluminum hydroxide + Deferasirox Majeure
- Amikacin + Deferasirox Majeure
- Argatroban + Deferasirox Majeure
- Aspirin / citric acid / sodium bicarbonate + Deferasirox Majeure
Autres interactions de Daprodustat
- Daprodustat + Gemfibrozil Contre-indiquée
- Abiraterone + Daprodustat Modérée
- Alogliptin-pioglitazone + Daprodustat Modérée
- Carbamazepine + Daprodustat Modérée
- Clopidogrel + Daprodustat Modérée
- Daprodustat + Hydrochlorothiazide-irbesartan Modérée
Questions fréquentes
Can I take Daprodustat with Deferasirox?
MediHelp rates the interaction as moderate. Daprodustat and Deferasirox can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox inhibits CYP2C8 to a moderate degree, and daprodustat is cleared mainly by CYP2C8. Exposure to daprodustat can rise, with a greater erythropoietic response and the risk of excessive hemoglobin increases.
How serious is the interaction between Daprodustat and Deferasirox?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Halve the daprodustat starting dose when it is started with deferasirox, unless the starting dose is already 1 mg. Monitor hemoglobin and adjust the dose when deferasirox is started or stopped.
What other medicines interact with Deferasirox?
MediHelp also lists interactions of Deferasirox with, for example, Acetylsalicylic acid, Alosetron, Aluminum hydroxide. The full list is on the Deferasirox page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
