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Interactions médicamenteuses

Amantadine + Amisulpride

Gravité: Modérée

Amantadine and Amisulpride: moderate interaction.

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Résumé

Amantadine enhances dopaminergic transmission while amisulpride blocks dopamine D2/D3 receptors, so each can blunt the effect of the other. Antipsychotic efficacy may be reduced and parkinsonian symptoms may worsen, while dopaminergic agents can aggravate psychosis.

Ce que signifie cette interaction, en termes simples

Amantadine and Amisulpride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Amantadine belongs to Anti Virals; Amisulpride belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Pharmacodynamic antagonism between dopamine-enhancing amantadine and the D2/D3 antagonist amisulpride.

Conduite à tenir

Avoid the combination when possible, especially in Parkinson disease; if both are needed, monitor psychiatric symptoms and motor function and adjust doses accordingly.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amantadine with Amisulpride?

MediHelp rates the interaction as moderate. Amantadine and Amisulpride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amantadine enhances dopaminergic transmission while amisulpride blocks dopamine D2/D3 receptors, so each can blunt the effect of the other. Antipsychotic efficacy may be reduced and parkinsonian symptoms may worsen, while dopaminergic agents can aggravate psychosis.

How serious is the interaction between Amantadine and Amisulpride?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible, especially in Parkinson disease; if both are needed, monitor psychiatric symptoms and motor function and adjust doses accordingly.

What other medicines interact with Amantadine?

MediHelp also lists interactions of Amantadine with, for example, Ethanol, Memantine-donepezil, Metoclopramide. The full list is on the Amantadine page.

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