Interactions médicamenteuses
Amantadine + Trospium
Gravité: Modérée
Amantadine and Trospium: moderate interaction.
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Résumé
Amantadine has anticholinergic properties and may add to the antimuscarinic effects of trospium. This can cause dry mouth, constipation, urinary retention and confusion, particularly in older adults. Because both drugs are renally eliminated, impaired renal function can also raise exposure.
Ce que signifie cette interaction, en termes simples
Amantadine and Trospium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amantadine belongs to Anti Virals; Trospium belongs to Genitourinary.
Pourquoi elle survient
Additive anticholinergic effects; both drugs are also renally cleared and may compete for tubular secretion.
Conduite à tenir
Monitor for anticholinergic effects and cognitive changes, and check renal function. Reduce doses if adverse effects appear.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Trospium
- Clozapine + Trospium Majeure
- Pramlintide + Trospium Majeure
- Thioridazine + Trospium Majeure
- Trihexyphenidyl + Trospium Majeure
- Aclidinium + Trospium Modérée
- Amitriptyline + Trospium Modérée
Autres interactions de Amantadine
- Amantadine + Ethanol Majeure
- Amantadine + Memantine-donepezil Majeure
- Amantadine + Metoclopramide Majeure
- Amantadine + Metoclopramide intranasal Majeure
- Amantadine + Amifampridine Modérée
- Amantadine + Amisulpride Modérée
Questions fréquentes
Can I take Amantadine with Trospium?
MediHelp rates the interaction as moderate. Amantadine and Trospium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amantadine has anticholinergic properties and may add to the antimuscarinic effects of trospium. This can cause dry mouth, constipation, urinary retention and confusion, particularly in older adults. Because both drugs are renally eliminated, impaired renal function can also raise exposure.
How serious is the interaction between Amantadine and Trospium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and cognitive changes, and check renal function. Reduce doses if adverse effects appear.
What other medicines interact with Trospium?
MediHelp also lists interactions of Trospium with, for example, Clozapine, Pramlintide, Thioridazine. The full list is on the Trospium page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
