Interactions médicamenteuses
Thioridazine + Trospium
Gravité: Majeure
Thioridazine and Trospium: major interaction.
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Résumé
Thioridazine has strong anticholinergic activity, which adds substantially to the effects of trospium. Constipation, urinary retention, dry mouth, confusion and tachycardia are more likely, and thioridazine also carries a serious QT prolongation risk.
Ce que signifie cette interaction, en termes simples
Thioridazine and Trospium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Thioridazine belongs to Central Nervous System; Trospium belongs to Genitourinary.
Pourquoi elle survient
Additive antimuscarinic pharmacodynamic effects.
Conduite à tenir
Avoid the combination where possible, especially in older patients. If used, monitor anticholinergic effects and ECG with electrolytes as required for thioridazine.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Trospium
- Clozapine + Trospium Majeure
- Pramlintide + Trospium Majeure
- Trihexyphenidyl + Trospium Majeure
- Aclidinium + Trospium Modérée
- Amantadine + Trospium Modérée
- Amitriptyline + Trospium Modérée
Autres interactions de Thioridazine
- Abiraterone + Thioridazine Contre-indiquée
- Adagrasib + Thioridazine Contre-indiquée
- Amiodarone + Thioridazine Contre-indiquée
- Amisulpride + Thioridazine Contre-indiquée
- Amitriptyline + Thioridazine Contre-indiquée
- Amoxapine + Thioridazine Contre-indiquée
Questions fréquentes
Can I take Thioridazine with Trospium?
MediHelp rates the interaction as major. Thioridazine and Trospium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Thioridazine has strong anticholinergic activity, which adds substantially to the effects of trospium. Constipation, urinary retention, dry mouth, confusion and tachycardia are more likely, and thioridazine also carries a serious QT prolongation risk.
How serious is the interaction between Thioridazine and Trospium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, especially in older patients. If used, monitor anticholinergic effects and ECG with electrolytes as required for thioridazine.
What other medicines interact with Trospium?
MediHelp also lists interactions of Trospium with, for example, Clozapine, Pramlintide, Trihexyphenidyl. The full list is on the Trospium page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
