Interactions médicamenteuses
Amifampridine + Galantamine
Gravité: Modérée
Amifampridine and Galantamine: moderate interaction.
Dernière mise à jour
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Résumé
Both drugs increase cholinergic transmission, by cholinesterase inhibition and by potassium channel blockade with enhanced acetylcholine release respectively. Combined use may produce additive cholinergic effects such as abdominal cramping, diarrhea, salivation, bradycardia and bronchospasm. Amifampridine also lowers seizure threshold.
Ce que signifie cette interaction, en termes simples
Amifampridine and Galantamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifampridine belongs to Central Nervous System; Galantamine belongs to Central Nervous System.
Pourquoi elle survient
Additive cholinergic effect: increased acetylcholine release plus reduced acetylcholine breakdown.
Conduite à tenir
Monitor for cholinergic adverse effects, heart rate and seizures, and reduce one agent if symptoms occur.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Galantamine
- Galantamine + Memantine-donepezil Majeure
- Galantamine + Physostigmine Majeure
- Galantamine + Ponesimod Majeure
- Galantamine + Rivastigmine Majeure
- Amiodarone + Galantamine Modérée
- Amitriptyline + Galantamine Modérée
Autres interactions de Amifampridine
- Amifampridine + Bupropion-naltrexone Majeure
- Amantadine + Amifampridine Modérée
- Amifampridine + Amitriptyline Modérée
- Amifampridine + Baclofen Modérée
- Amifampridine + Bethanechol Modérée
- Amifampridine + Bromocriptine Modérée
Questions fréquentes
Can I take Amifampridine with Galantamine?
MediHelp rates the interaction as moderate. Amifampridine and Galantamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs increase cholinergic transmission, by cholinesterase inhibition and by potassium channel blockade with enhanced acetylcholine release respectively. Combined use may produce additive cholinergic effects such as abdominal cramping, diarrhea, salivation, bradycardia and bronchospasm. Amifampridine also lowers seizure threshold.
How serious is the interaction between Amifampridine and Galantamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cholinergic adverse effects, heart rate and seizures, and reduce one agent if symptoms occur.
What other medicines interact with Galantamine?
MediHelp also lists interactions of Galantamine with, for example, Memantine-donepezil, Physostigmine, Ponesimod. The full list is on the Galantamine page.
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