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Interactions médicamenteuses

Amitriptyline + Galantamine

Gravité: Modérée

Amitriptyline and Galantamine: moderate interaction.

Dernière mise à jour

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Résumé

Amitriptyline has strong anticholinergic activity that opposes the cholinergic action of galantamine, potentially reducing its benefit in dementia. Anticholinergic burden may also worsen cognition and confusion.

Ce que signifie cette interaction, en termes simples

Amitriptyline and Galantamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Amitriptyline belongs to Central Nervous System; Galantamine belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Pharmacodynamic antagonism between muscarinic blockade by amitriptyline and cholinesterase inhibition by galantamine.

Conduite à tenir

Avoid amitriptyline in patients with dementia where possible and choose a less anticholinergic antidepressant. If combined, monitor cognitive response.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amitriptyline with Galantamine?

MediHelp rates the interaction as moderate. Amitriptyline and Galantamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amitriptyline has strong anticholinergic activity that opposes the cholinergic action of galantamine, potentially reducing its benefit in dementia. Anticholinergic burden may also worsen cognition and confusion.

How serious is the interaction between Amitriptyline and Galantamine?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid amitriptyline in patients with dementia where possible and choose a less anticholinergic antidepressant. If combined, monitor cognitive response.

What other medicines interact with Amitriptyline?

MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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