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Interactions médicamenteuses

Galantamine + Rivastigmine

Gravité: Majeure

Galantamine and Rivastigmine: major interaction.

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Résumé

Both are cholinesterase inhibitors, so using them together duplicates therapy and increases cholinergic toxicity without added benefit. Nausea, vomiting, diarrhea, bradycardia and syncope are more likely.

Ce que signifie cette interaction, en termes simples

Galantamine and Rivastigmine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Galantamine belongs to Central Nervous System; Rivastigmine belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Duplicate acetylcholinesterase inhibition leading to additive cholinergic effects.

Conduite à tenir

Avoid concurrent use and use only one cholinesterase inhibitor. When switching, stop one and start the other at its initial dose.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Galantamine with Rivastigmine?

MediHelp rates the interaction as major. Galantamine and Rivastigmine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are cholinesterase inhibitors, so using them together duplicates therapy and increases cholinergic toxicity without added benefit. Nausea, vomiting, diarrhea, bradycardia and syncope are more likely.

How serious is the interaction between Galantamine and Rivastigmine?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and use only one cholinesterase inhibitor. When switching, stop one and start the other at its initial dose.

What other medicines interact with Rivastigmine?

MediHelp also lists interactions of Rivastigmine with, for example, Donepezil, Memantine-donepezil, Metoclopramide. The full list is on the Rivastigmine page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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