Interactions médicamenteuses
Amikacin + Cefuroxime
Gravité: Modérée
Amikacin and Cefuroxime: moderate interaction.
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Résumé
Cefuroxime given with amikacin may increase the risk of kidney injury, especially in older, dehydrated or renally impaired patients. Amikacin is the principal nephrotoxic and ototoxic agent, and the combination is often used on purpose in serious infections.
Ce que signifie cette interaction, en termes simples
Amikacin and Cefuroxime can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Cefuroxime belongs to Anti Bacterial.
Pourquoi elle survient
Additive nephrotoxic potential; cephalosporins may modestly add to aminoglycoside tubular injury.
Conduite à tenir
Monitor serum creatinine and amikacin levels, keep the patient hydrated and limit the aminoglycoside duration. Adjust the doses for renal function.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Cefuroxime
- Aluminum hydroxide + Cefuroxime Modérée
- Bcg vaccine live + Cefuroxime Modérée
- Calcium carbonate + Cefuroxime Modérée
- Calcium + Cefuroxime Modérée
- Cefuroxime + Cholera vaccine Modérée
- Cefuroxime + Cimetidine Modérée
Autres interactions de Amikacin
- Amikacin + Cidofovir Contre-indiquée
- Adefovir + Amikacin Majeure
- Amikacin + Amphotericin b Majeure
- Amikacin + Amphotericin b deoxycholate Majeure
- Amikacin + Atracurium Majeure
- Amikacin + Bacitracin Majeure
Questions fréquentes
Can I take Amikacin with Cefuroxime?
MediHelp rates the interaction as moderate. Amikacin and Cefuroxime can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cefuroxime given with amikacin may increase the risk of kidney injury, especially in older, dehydrated or renally impaired patients. Amikacin is the principal nephrotoxic and ototoxic agent, and the combination is often used on purpose in serious infections.
How serious is the interaction between Amikacin and Cefuroxime?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and amikacin levels, keep the patient hydrated and limit the aminoglycoside duration. Adjust the doses for renal function.
What other medicines interact with Cefuroxime?
MediHelp also lists interactions of Cefuroxime with, for example, Aluminum hydroxide, Bcg vaccine live, Calcium carbonate. The full list is on the Cefuroxime page.
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