Interactions médicamenteuses
Amiloride + Amlodipine-olmesartan-hydrochlorothiazide
Gravité: Majeure
Amiloride and Amlodipine-olmesartan-hydrochlorothiazide: major interaction.
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Résumé
Olmesartan and amiloride both reduce potassium excretion and can cause hyperkalemia, which hydrochlorothiazide only partly offsets. The risk is highest with renal impairment, diabetes or older age.
Ce que signifie cette interaction, en termes simples
Amiloride and Amlodipine-olmesartan-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiloride belongs to Cardiovascular; Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular.
Pourquoi elle survient
Additive reduction of renal potassium excretion by angiotensin receptor blockade and ENaC inhibition, partly opposed by thiazide kaliuresis.
Conduite à tenir
Monitor serum potassium and renal function soon after starting and periodically thereafter. Stop amiloride and avoid potassium supplements if hyperkalemia develops.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contre-indiquée
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contre-indiquée
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contre-indiquée
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Majeure
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Majeure
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Majeure
Autres interactions de Amiloride
- Amiloride + Eplerenone Contre-indiquée
- Amiloride + Spironolactone Contre-indiquée
- Amiloride + Triamterene Contre-indiquée
- Aceclofenac + Amiloride Majeure
- Acemetacin + Amiloride Majeure
- Amiloride + Amlodipine-benazepril Majeure
Questions fréquentes
Can I take Amiloride with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp rates the interaction as major. Amiloride and Amlodipine-olmesartan-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Olmesartan and amiloride both reduce potassium excretion and can cause hyperkalemia, which hydrochlorothiazide only partly offsets. The risk is highest with renal impairment, diabetes or older age.
How serious is the interaction between Amiloride and Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function soon after starting and periodically thereafter. Stop amiloride and avoid potassium supplements if hyperkalemia develops.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
