Interactions médicamenteuses
Amiloride + Indomethacin
Gravité: Majeure
Amiloride and Indomethacin: major interaction.
Dernière mise à jour Sources: US FDA label
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Résumé
Indomethacin can blunt renal potassium excretion while amiloride is potassium-sparing, so combined use can cause hyperkalemia. NSAIDs may also reduce the diuretic and antihypertensive effect of amiloride and worsen renal function.
Ce que signifie cette interaction, en termes simples
Amiloride and Indomethacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiloride belongs to Cardiovascular; Indomethacin belongs to Musculoskeletal.
Pourquoi elle survient
Additive potassium retention: amiloride blocks ENaC and indomethacin suppresses prostaglandin-mediated renin and aldosterone and renal potassium excretion.
Conduite à tenir
Avoid the combination where possible; if used, monitor serum potassium and creatinine within the first week and periodically after, especially in the elderly, diabetics or those with renal impairment.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Références
Autres interactions de Indomethacin
- Indomethacin + Ketorolac Contre-indiquée
- Indomethacin + Ketorolac intranasal Contre-indiquée
- Aceclofenac + Indomethacin Majeure
- Acemetacin + Indomethacin Majeure
- Acetylsalicylic acid + Indomethacin Majeure
- Alteplase + Indomethacin Majeure
Autres interactions de Amiloride
- Amiloride + Eplerenone Contre-indiquée
- Amiloride + Spironolactone Contre-indiquée
- Amiloride + Triamterene Contre-indiquée
- Aceclofenac + Amiloride Majeure
- Acemetacin + Amiloride Majeure
- Amiloride + Amlodipine-benazepril Majeure
Questions fréquentes
Can I take Amiloride with Indomethacin?
MediHelp rates the interaction as major. Amiloride and Indomethacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Indomethacin can blunt renal potassium excretion while amiloride is potassium-sparing, so combined use can cause hyperkalemia. NSAIDs may also reduce the diuretic and antihypertensive effect of amiloride and worsen renal function.
How serious is the interaction between Amiloride and Indomethacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, monitor serum potassium and creatinine within the first week and periodically after, especially in the elderly, diabetics or those with renal impairment.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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