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Interactions médicamenteuses

Amiodarone + Bisoprolol

Gravité: Majeure

Amiodarone and Bisoprolol: major interaction.

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Résumé

Both drugs slow heart rate and AV conduction, and the combination can cause severe bradycardia, AV block or sinus arrest. Amiodarone's long half-life means the risk persists after discontinuation.

Ce que signifie cette interaction, en termes simples

Amiodarone and Bisoprolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Amiodarone belongs to Cardiovascular; Bisoprolol belongs to Cardiovascular.

Niveau de preuve: High

Pourquoi elle survient

Additive negative chronotropic and dromotropic effects from beta-blockade and amiodarone's sodium, calcium and potassium channel and beta-blocking actions.

Conduite à tenir

Monitor heart rate and ECG, especially at initiation, and reduce the bisoprolol dose or stop one agent if symptomatic bradycardia or conduction block develops.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amiodarone with Bisoprolol?

MediHelp rates the interaction as major. Amiodarone and Bisoprolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs slow heart rate and AV conduction, and the combination can cause severe bradycardia, AV block or sinus arrest. Amiodarone's long half-life means the risk persists after discontinuation.

How serious is the interaction between Amiodarone and Bisoprolol?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG, especially at initiation, and reduce the bisoprolol dose or stop one agent if symptomatic bradycardia or conduction block develops.

What other medicines interact with Bisoprolol?

MediHelp also lists interactions of Bisoprolol with, for example, Aldesleukin, Amifostine, Atenolol-chlorthalidone. The full list is on the Bisoprolol page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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