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Interactions médicamenteuses

Amiodarone + Ribociclib

Gravité: Contre-indiquée

Amiodarone and Ribociclib: contraindicated interaction.

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Résumé

Ribociclib prolongs the QT interval dose-dependently and amiodarone has strong QT effects, so the combination is hazardous. Ribociclib also inhibits CYP3A4, which may increase amiodarone exposure.

Ce que signifie cette interaction, en termes simples

Amiodarone and Ribociclib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Amiodarone belongs to Cardiovascular; Ribociclib belongs to Oncology.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive QT prolongation combined with CYP3A4 inhibition by ribociclib.

Conduite à tenir

Avoid the combination and use an alternative antiarrhythmic. If it cannot be avoided, monitor ECG and electrolytes intensively with ribociclib dose reduction per labeling.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amiodarone with Ribociclib?

MediHelp rates the interaction as contraindicated. Amiodarone and Ribociclib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ribociclib prolongs the QT interval dose-dependently and amiodarone has strong QT effects, so the combination is hazardous. Ribociclib also inhibits CYP3A4, which may increase amiodarone exposure.

How serious is the interaction between Amiodarone and Ribociclib?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative antiarrhythmic. If it cannot be avoided, monitor ECG and electrolytes intensively with ribociclib dose reduction per labeling.

What other medicines interact with Amiodarone?

MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.

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