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Interactions médicamenteuses

Amitriptyline + Azelastine

Gravité: Modérée

Amitriptyline and Azelastine: moderate interaction.

Dernière mise à jour

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Résumé

Both drugs have sedative properties, and amitriptyline also has strong anticholinergic effects. Concurrent use may increase drowsiness, dizziness and impaired psychomotor performance.

Ce que signifie cette interaction, en termes simples

Amitriptyline and Azelastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Amitriptyline belongs to Central Nervous System; Azelastine belongs to Respiratory.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive CNS depression via H1-receptor antagonism from both agents, plus anticholinergic effects of amitriptyline.

Conduite à tenir

Counsel on additive sedation and avoid driving until tolerance is established. Monitor elderly patients for confusion and falls.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amitriptyline with Azelastine?

MediHelp rates the interaction as moderate. Amitriptyline and Azelastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have sedative properties, and amitriptyline also has strong anticholinergic effects. Concurrent use may increase drowsiness, dizziness and impaired psychomotor performance.

How serious is the interaction between Amitriptyline and Azelastine?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on additive sedation and avoid driving until tolerance is established. Monitor elderly patients for confusion and falls.

What other medicines interact with Azelastine?

MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.

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