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Interactions médicamenteuses

Amitriptyline + Bethanechol

Gravité: Modérée

Amitriptyline and Bethanechol: moderate interaction.

Dernière mise à jour

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Résumé

Amitriptyline has strong anticholinergic activity that directly opposes the muscarinic effects of bethanechol. This can reduce bethanechol's benefit in urinary retention and may worsen retention caused by the antidepressant.

Ce que signifie cette interaction, en termes simples

Amitriptyline and Bethanechol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Amitriptyline belongs to Central Nervous System; Bethanechol belongs to Gastrointestinal Tract.

Niveau de preuve: Moderate

Pourquoi elle survient

Pharmacodynamic antagonism between a muscarinic agonist and a muscarinic antagonist.

Conduite à tenir

Monitor urinary symptoms and bethanechol response. Consider a less anticholinergic antidepressant if retention persists.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amitriptyline with Bethanechol?

MediHelp rates the interaction as moderate. Amitriptyline and Bethanechol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amitriptyline has strong anticholinergic activity that directly opposes the muscarinic effects of bethanechol. This can reduce bethanechol's benefit in urinary retention and may worsen retention caused by the antidepressant.

How serious is the interaction between Amitriptyline and Bethanechol?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urinary symptoms and bethanechol response. Consider a less anticholinergic antidepressant if retention persists.

What other medicines interact with Bethanechol?

MediHelp also lists interactions of Bethanechol with, for example, Darifenacin, Fesoterodine, Oxybutynin. The full list is on the Bethanechol page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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