Interactions médicamenteuses
Amitriptyline + Budesonide-formoterol
Gravité: Majeure
Amitriptyline and Budesonide-formoterol: major interaction.
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Résumé
Formoterol can prolong the QT interval and raise heart rate, and amitriptyline has its own QT-prolonging and proarrhythmic effects. Tricyclics can also potentiate the cardiovascular effects of beta-agonists, so the combination may raise the risk of tachyarrhythmia and palpitations.
Ce que signifie cette interaction, en termes simples
Amitriptyline and Budesonide-formoterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Budesonide-formoterol belongs to Respiratory.
Pourquoi elle survient
Additive QT prolongation and adrenergic cardiovascular stimulation, with tricyclic potentiation of sympathomimetic effects.
Conduite à tenir
Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor QTc and heart rate, and consider alternatives in patients with cardiac disease or other QT risk factors.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Budesonide-formoterol
Autres interactions de Amitriptyline
- Amitriptyline + Isocarboxazid Contre-indiquée
- Amitriptyline + Methylene blue Contre-indiquée
- Amitriptyline + Phenelzine Contre-indiquée
- Amitriptyline + Pimozide Contre-indiquée
- Amitriptyline + Procarbazine Contre-indiquée
- Amitriptyline + Safinamide Contre-indiquée
Questions fréquentes
Can I take Amitriptyline with Budesonide-formoterol?
MediHelp rates the interaction as major. Amitriptyline and Budesonide-formoterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Formoterol can prolong the QT interval and raise heart rate, and amitriptyline has its own QT-prolonging and proarrhythmic effects. Tricyclics can also potentiate the cardiovascular effects of beta-agonists, so the combination may raise the risk of tachyarrhythmia and palpitations.
How serious is the interaction between Amitriptyline and Budesonide-formoterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor QTc and heart rate, and consider alternatives in patients with cardiac disease or other QT risk factors.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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