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Interactions médicamenteuses

Amitriptyline + Formoterol

Gravité: Majeure

Amitriptyline and Formoterol: major interaction.

Dernière mise à jour Sources: US FDA label

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Résumé

Amitriptyline and formoterol can each prolong the QT interval, and tricyclics also potentiate adrenergic cardiovascular effects. Together they may cause tachycardia and ventricular arrhythmias, particularly in patients with heart disease.

Ce que signifie cette interaction, en termes simples

Amitriptyline and Formoterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Amitriptyline belongs to Central Nervous System; Formoterol belongs to Respiratory.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive QT prolongation and tricyclic-mediated potentiation of beta-agonist adrenergic effects via norepinephrine reuptake blockade.

Conduite à tenir

Obtain a baseline ECG and monitor QTc, heart rate and potassium. Avoid in patients with long QT or significant cardiac disease where alternatives exist.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Références

Questions fréquentes

Can I take Amitriptyline with Formoterol?

MediHelp rates the interaction as major. Amitriptyline and Formoterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amitriptyline and formoterol can each prolong the QT interval, and tricyclics also potentiate adrenergic cardiovascular effects. Together they may cause tachycardia and ventricular arrhythmias, particularly in patients with heart disease.

How serious is the interaction between Amitriptyline and Formoterol?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc, heart rate and potassium. Avoid in patients with long QT or significant cardiac disease where alternatives exist.

What other medicines interact with Formoterol?

MediHelp also lists interactions of Formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Formoterol page.

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