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Interactions médicamenteuses

Amlodipine-olmesartan-hydrochlorothiazide + Benazepril

Gravité: Majeure

Amlodipine-olmesartan-hydrochlorothiazide and Benazepril: major interaction.

Dernière mise à jour

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Résumé

Combining an angiotensin receptor blocker with an ACE inhibitor produces dual blockade of the renin-angiotensin system. This raises the risk of hypotension, hyperkalemia and acute kidney injury, and outcome trials showed no cardiovascular benefit over a single agent in most patients.

Ce que signifie cette interaction, en termes simples

Amlodipine-olmesartan-hydrochlorothiazide and Benazepril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Benazepril belongs to Cardiovascular.

Niveau de preuve: High

Pourquoi elle survient

Additive pharmacodynamic inhibition of the renin-angiotensin-aldosterone system at two sites, which reduces glomerular filtration pressure and aldosterone-mediated potassium excretion.

Conduite à tenir

Avoid the combination and use only one RAS blocker. If it is unavoidable, monitor serum potassium, creatinine and blood pressure closely.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amlodipine-olmesartan-hydrochlorothiazide with Benazepril?

MediHelp rates the interaction as major. Amlodipine-olmesartan-hydrochlorothiazide and Benazepril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an angiotensin receptor blocker with an ACE inhibitor produces dual blockade of the renin-angiotensin system. This raises the risk of hypotension, hyperkalemia and acute kidney injury, and outcome trials showed no cardiovascular benefit over a single agent in most patients.

How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Benazepril?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use only one RAS blocker. If it is unavoidable, monitor serum potassium, creatinine and blood pressure closely.

What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?

MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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