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Interactions médicamenteuses

Benazepril + Sacubitril-valsartan

Gravité: Contre-indiquée

Benazepril and Sacubitril-valsartan: contraindicated interaction.

Dernière mise à jour

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Résumé

Sacubitril inhibits neprilysin and so increases bradykinin, as does the ACE inhibitor benazepril. Combined, the rise in bradykinin substantially increases the risk of angioedema, which can involve the airway.

Ce que signifie cette interaction, en termes simples

Benazepril and Sacubitril-valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Benazepril belongs to Cardiovascular; Sacubitril-valsartan belongs to Cardiovascular.

Niveau de preuve: High

Pourquoi elle survient

Neprilysin plus ACE inhibition causes additive bradykinin accumulation

Conduite à tenir

Contraindicated: stop the ACE inhibitor at least 36 hours before starting sacubitril/valsartan and do not restart one within 36 hours of the other.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Benazepril with Sacubitril-valsartan?

MediHelp rates the interaction as contraindicated. Benazepril and Sacubitril-valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sacubitril inhibits neprilysin and so increases bradykinin, as does the ACE inhibitor benazepril. Combined, the rise in bradykinin substantially increases the risk of angioedema, which can involve the airway.

How serious is the interaction between Benazepril and Sacubitril-valsartan?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Contraindicated: stop the ACE inhibitor at least 36 hours before starting sacubitril/valsartan and do not restart one within 36 hours of the other.

What other medicines interact with Sacubitril-valsartan?

MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Captopril, Enalapril. The full list is on the Sacubitril-valsartan page.

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