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Interactions médicamenteuses

Amlodipine-hydrochlorothiazide-valsartan + Benazepril

Gravité: Majeure

Amlodipine-hydrochlorothiazide-valsartan and Benazepril: major interaction.

Dernière mise à jour

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Résumé

Adding an ACE inhibitor to a regimen already containing the angiotensin receptor blocker valsartan produces dual renin-angiotensin system blockade. This raises the risk of symptomatic hypotension, hyperkalemia and acute kidney injury without a meaningful cardiovascular benefit in most patients.

Ce que signifie cette interaction, en termes simples

Amlodipine-hydrochlorothiazide-valsartan and Benazepril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Benazepril belongs to Cardiovascular.

Niveau de preuve: High

Pourquoi elle survient

Additive pharmacodynamic inhibition of the renin-angiotensin-aldosterone system at two different points, reducing glomerular filtration pressure and aldosterone-mediated potassium excretion.

Conduite à tenir

Avoid the combination and use a single renin-angiotensin agent. If it is unavoidable, monitor blood pressure, serum potassium and creatinine closely.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amlodipine-hydrochlorothiazide-valsartan with Benazepril?

MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Benazepril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Adding an ACE inhibitor to a regimen already containing the angiotensin receptor blocker valsartan produces dual renin-angiotensin system blockade. This raises the risk of symptomatic hypotension, hyperkalemia and acute kidney injury without a meaningful cardiovascular benefit in most patients.

How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Benazepril?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a single renin-angiotensin agent. If it is unavoidable, monitor blood pressure, serum potassium and creatinine closely.

What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?

MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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