Interactions médicamenteuses
Amobarbital + Norethisterone
Gravité: Majeure
Amobarbital and Norethisterone: major interaction.
Dernière mise à jour Sources: UK SmPC
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Résumé
Barbiturates induce hepatic enzymes and can lower norethisterone concentrations. This may lead to breakthrough bleeding and contraceptive failure.
Ce que signifie cette interaction, en termes simples
Amobarbital and Norethisterone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Norethisterone belongs to Endocrine.
Pourquoi elle survient
Amobarbital induces CYP3A4 and other hepatic enzymes, increasing the clearance of norethisterone.
Conduite à tenir
Use a non-hormonal or non-enzyme-dependent contraceptive method such as a copper IUD or injectable. Continue extra protection for several weeks after stopping the barbiturate.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Références
- Norethisterone 5mg Tablets - SmPC sections 4.3/4.5 (class statement: compounds known to induce drug-metabolising enzymes; "The metabolism of progestogens may be increased by concomitant administration of compounds known to induce drug-metabolising enzymes, specifically cytochrome P4") — electronic medicines compendium (UK SmPC)
Autres interactions de Norethisterone
- Acitretin + Norethisterone Contre-indiquée
- Apalutamide + Norethisterone Majeure
- Belzutifan + Norethisterone Majeure
- Bosentan + Norethisterone Majeure
- Brigatinib + Norethisterone Majeure
- Carbamazepine + Norethisterone Majeure
Autres interactions de Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contre-indiquée
- Amobarbital + Doravirine Contre-indiquée
- Amobarbital + Elbasvir / grazoprevir Contre-indiquée
- Amobarbital + Isavuconazonium Contre-indiquée
- Amobarbital + Isocarboxazid Contre-indiquée
- Amobarbital + Lonafarnib Contre-indiquée
Questions fréquentes
Can I take Amobarbital with Norethisterone?
MediHelp rates the interaction as major. Amobarbital and Norethisterone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates induce hepatic enzymes and can lower norethisterone concentrations. This may lead to breakthrough bleeding and contraceptive failure.
How serious is the interaction between Amobarbital and Norethisterone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-hormonal or non-enzyme-dependent contraceptive method such as a copper IUD or injectable. Continue extra protection for several weeks after stopping the barbiturate.
What other medicines interact with Norethisterone?
MediHelp also lists interactions of Norethisterone with, for example, Acitretin, Apalutamide, Belzutifan. The full list is on the Norethisterone page.
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