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Interactions médicamenteuses

Amobarbital + Isavuconazonium

Gravité: Contre-indiquée

Amobarbital and Isavuconazonium: contraindicated interaction.

Dernière mise à jour

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Résumé

Inducers of CYP3A4 such as barbiturates lower isavuconazole concentrations considerably. Subtherapeutic exposure risks failure of treatment of serious invasive fungal infection. Strong inducers are contraindicated in the labeling.

Ce que signifie cette interaction, en termes simples

Amobarbital and Isavuconazonium are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Amobarbital belongs to Central Nervous System; Isavuconazonium belongs to Anti Fungals.

Niveau de preuve: Moderate

Pourquoi elle survient

Barbiturate-mediated CYP3A4 induction increases isavuconazole clearance.

Conduite à tenir

Avoid the combination and choose a non-inducing sedative. If an inducer is essential, consider a different antifungal.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amobarbital with Isavuconazonium?

MediHelp rates the interaction as contraindicated. Amobarbital and Isavuconazonium are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Inducers of CYP3A4 such as barbiturates lower isavuconazole concentrations considerably. Subtherapeutic exposure risks failure of treatment of serious invasive fungal infection. Strong inducers are contraindicated in the labeling.

How serious is the interaction between Amobarbital and Isavuconazonium?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-inducing sedative. If an inducer is essential, consider a different antifungal.

What other medicines interact with Amobarbital?

MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.

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