Aller au contenu
MediHelp
MediHelp Référence médicamenteuse

Interactions médicamenteuses

Amobarbital + Lonafarnib

Gravité: Contre-indiquée

Amobarbital and Lonafarnib: contraindicated interaction.

Dernière mise à jour

Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.

Le contenu clinique de cette page n'est disponible qu'en anglais.

Résumé

Lonafarnib is a sensitive CYP3A4 substrate, so enzyme induction by amobarbital can greatly reduce its exposure. This could cause loss of efficacy. Labeling prohibits use with strong or moderate CYP3A inducers.

Ce que signifie cette interaction, en termes simples

Amobarbital and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Amobarbital belongs to Central Nervous System; Lonafarnib belongs to Miscellaneous.

Niveau de preuve: Moderate

Pourquoi elle survient

Barbiturate-mediated CYP3A4 induction increases lonafarnib metabolism.

Conduite à tenir

Avoid the combination. Select a non-inducing alternative to amobarbital.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Réservé aux membres Pro+

Débloquer la page complète

Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Amobarbital et Lonafarnib, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
Créer un compte gratuit Se connecter

Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.

Questions fréquentes

Can I take Amobarbital with Lonafarnib?

MediHelp rates the interaction as contraindicated. Amobarbital and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lonafarnib is a sensitive CYP3A4 substrate, so enzyme induction by amobarbital can greatly reduce its exposure. This could cause loss of efficacy. Labeling prohibits use with strong or moderate CYP3A inducers.

How serious is the interaction between Amobarbital and Lonafarnib?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Select a non-inducing alternative to amobarbital.

What other medicines interact with Amobarbital?

MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

Télécharger surApp Store Disponible surGoogle Play

Parcourir de A à Z · Interactions médicamenteuses

Télécharger l'app Se connecter