Interactions médicamenteuses
Amoxicillin + Methotrexate
Gravité: Majeure
Amoxicillin and Methotrexate: major interaction.
Dernière mise à jour Sources: US FDA label
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Résumé
Penicillins such as amoxicillin can reduce methotrexate clearance and have been reported to raise methotrexate levels, causing myelosuppression and mucositis. The effect is mainly reported with high-dose methotrexate and in renal impairment, and is less predictable with low-dose therapy. Evidence is based on case reports and pharmacokinetic observations.
Ce que signifie cette interaction, en termes simples
Amoxicillin and Methotrexate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amoxicillin belongs to Anti Bacterial; Methotrexate belongs to Oncology.
Pourquoi elle survient
Penicillins compete with methotrexate for renal tubular secretion via organic anion transporters, reducing its elimination.
Conduite à tenir
Where possible choose an antibiotic with less renal interaction potential, particularly during high-dose methotrexate. If amoxicillin is needed, monitor full blood count, renal function and methotrexate levels where available.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Références
Autres interactions de Methotrexate
- Acitretin + Methotrexate Contre-indiquée
- Adenovirus types 4 and 7 live + Methotrexate Contre-indiquée
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contre-indiquée
- Ketorolac + Methotrexate Contre-indiquée
- Measles mumps and rubella vaccine live + Methotrexate Contre-indiquée
- Measles mumps and rubella vaccine + Methotrexate Contre-indiquée
Autres interactions de Amoxicillin
- Amoxicillin + Bcg vaccine live Modérée
- Amoxicillin + Cholera vaccine Modérée
- Amoxicillin + Eravacycline Modérée
- Amoxicillin + Microbiota Modérée
- Amoxicillin + Mycophenolate Modérée
- Amoxicillin + Omadacycline Modérée
Questions fréquentes
Can I take Amoxicillin with Methotrexate?
MediHelp rates the interaction as major. Amoxicillin and Methotrexate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Penicillins such as amoxicillin can reduce methotrexate clearance and have been reported to raise methotrexate levels, causing myelosuppression and mucositis. The effect is mainly reported with high-dose methotrexate and in renal impairment, and is less predictable with low-dose therapy. Evidence is based on case reports and pharmacokinetic observations.
How serious is the interaction between Amoxicillin and Methotrexate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible choose an antibiotic with less renal interaction potential, particularly during high-dose methotrexate. If amoxicillin is needed, monitor full blood count, renal function and methotrexate levels where available.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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