Drug interactions
amoxicillin + methotrexate
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↑ MTX toxicity risk.
Mechanism of action
Competition for renal tubular secretion.
Clinical management
Avoid or monitor MTX levels and toxicity.
Drug reference
References
Frequently asked questions
Can I take amoxicillin with methotrexate?
The interaction is rated: Major. ↑ MTX toxicity risk.
How serious is the interaction between amoxicillin and methotrexate?
The interaction is rated: Major. Evidence level: Moderate.
How is the interaction between amoxicillin and methotrexate managed?
Avoid or monitor MTX levels and toxicity.
Why do amoxicillin and methotrexate interact?
Competition for renal tubular secretion.
Full monographs, dosing and an interaction checker in the MediHelp app
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