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Interactions médicamenteuses

Azathioprine + Pexidartinib

Gravité: Majeure

Azathioprine and Pexidartinib: major interaction.

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Résumé

Pexidartinib carries a risk of serious, sometimes fatal, liver injury, and azathioprine can also cause hepatotoxicity. Using both increases the risk of liver damage.

Ce que signifie cette interaction, en termes simples

Azathioprine and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Azathioprine belongs to Gastrointestinal Tract; Pexidartinib belongs to Oncology.

Niveau de preuve: Low

Pourquoi elle survient

Additive hepatotoxicity from two drugs that can independently injure the liver.

Conduite à tenir

Avoid coadministration where an alternative exists. If unavoidable, check liver tests at baseline and frequently during treatment, and stop pexidartinib if hepatotoxicity develops.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Azathioprine with Pexidartinib?

MediHelp rates the interaction as major. Azathioprine and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pexidartinib carries a risk of serious, sometimes fatal, liver injury, and azathioprine can also cause hepatotoxicity. Using both increases the risk of liver damage.

How serious is the interaction between Azathioprine and Pexidartinib?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration where an alternative exists. If unavoidable, check liver tests at baseline and frequently during treatment, and stop pexidartinib if hepatotoxicity develops.

What other medicines interact with Azathioprine?

MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.

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