Interactions médicamenteuses
Ampicillin-sulbactam + Omadacycline
Gravité: Modérée
Ampicillin-sulbactam and Omadacycline: moderate interaction.
Dernière mise à jour
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Résumé
Bacteriostatic tetracyclines have been theorized to blunt the killing activity of beta-lactams, which depend on actively dividing bacteria. Clinical evidence of reduced outcomes is limited and mostly derived from older studies and in vitro data. The concern is greatest in severe infections such as meningitis or endocarditis.
Ce que signifie cette interaction, en termes simples
Ampicillin-sulbactam and Omadacycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ampicillin-sulbactam belongs to Anti Bacterial; Omadacycline belongs to Anti Bacterial.
Pourquoi elle survient
Pharmacodynamic antagonism: a bacteriostatic protein synthesis inhibitor slows bacterial growth, reducing the activity of cell-wall-active bactericidal beta-lactams.
Conduite à tenir
Avoid combining when treating severe infections that need bactericidal therapy, and choose a single appropriate agent where possible. If both are required, monitor clinical response closely.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Ampicillin-sulbactam
Autres interactions de Omadacycline
- Acitretin + Omadacycline Contre-indiquée
- Isotretinoin + Omadacycline Majeure
- Omadacycline + Tretinoin Majeure
- Aluminum hydroxide + Omadacycline Modérée
- Amoxicillin-clavulanic acid + Omadacycline Modérée
- Amoxicillin + Omadacycline Modérée
Questions fréquentes
Can I take Ampicillin-sulbactam with Omadacycline?
MediHelp rates the interaction as moderate. Ampicillin-sulbactam and Omadacycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bacteriostatic tetracyclines have been theorized to blunt the killing activity of beta-lactams, which depend on actively dividing bacteria. Clinical evidence of reduced outcomes is limited and mostly derived from older studies and in vitro data. The concern is greatest in severe infections such as meningitis or endocarditis.
How serious is the interaction between Ampicillin-sulbactam and Omadacycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining when treating severe infections that need bactericidal therapy, and choose a single appropriate agent where possible. If both are required, monitor clinical response closely.
What other medicines interact with Ampicillin-sulbactam?
MediHelp also lists interactions of Ampicillin-sulbactam with, for example, Methotrexate, Allopurinol, Bcg vaccine live. The full list is on the Ampicillin-sulbactam page.
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