Drug interactions
Ampicillin-sulbactam + Omadacycline
Severity: Moderate
Ampicillin-sulbactam and Omadacycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bacteriostatic tetracyclines have been theorized to blunt the killing activity of beta-lactams, which depend on actively dividing bacteria. Clinical evidence of reduced outcomes is limited and mostly derived from older studies and in vitro data. The concern is greatest in severe infections such as meningitis or endocarditis.
What this interaction means in plain words
Ampicillin-sulbactam and Omadacycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ampicillin-sulbactam belongs to Anti Bacterial; Omadacycline belongs to Anti Bacterial.
Why it happens
Pharmacodynamic antagonism: a bacteriostatic protein synthesis inhibitor slows bacterial growth, reducing the activity of cell-wall-active bactericidal beta-lactams.
What to do
Avoid combining when treating severe infections that need bactericidal therapy, and choose a single appropriate agent where possible. If both are required, monitor clinical response closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ampicillin-sulbactam
Other interactions of Omadacycline
- Acitretin + Omadacycline Contraindicated
- Isotretinoin + Omadacycline Major
- Omadacycline + Tretinoin Major
- Aluminum hydroxide + Omadacycline Moderate
- Amoxicillin-clavulanic acid + Omadacycline Moderate
- Amoxicillin + Omadacycline Moderate
Frequently asked questions
Can I take Ampicillin-sulbactam with Omadacycline?
MediHelp rates the interaction as moderate. Ampicillin-sulbactam and Omadacycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bacteriostatic tetracyclines have been theorized to blunt the killing activity of beta-lactams, which depend on actively dividing bacteria. Clinical evidence of reduced outcomes is limited and mostly derived from older studies and in vitro data. The concern is greatest in severe infections such as meningitis or endocarditis.
How serious is the interaction between Ampicillin-sulbactam and Omadacycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining when treating severe infections that need bactericidal therapy, and choose a single appropriate agent where possible. If both are required, monitor clinical response closely.
What other medicines interact with Ampicillin-sulbactam?
MediHelp also lists interactions of Ampicillin-sulbactam with, for example, Methotrexate, Allopurinol, Bcg vaccine live. The full list is on the Ampicillin-sulbactam page.
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