Interactions médicamenteuses
Amyl nitrite + Tadalafil
Gravité: Contre-indiquée
Amyl nitrite and Tadalafil: contraindicated interaction.
Dernière mise à jour
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
Résumé
Amyl nitrite is a rapid, potent vasodilator, and tadalafil greatly enhances its hypotensive effect. Profound hypotension, collapse and cardiac ischemia can result, including with recreational inhaled nitrites.
Ce que signifie cette interaction, en termes simples
Amyl nitrite and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Nitrite-derived nitric oxide raises cGMP and PDE5 inhibition prevents its degradation, causing excessive additive vasodilation.
Conduite à tenir
Do not use together; allow at least 48 hours after the last tadalafil dose before any nitrate. Advise patients to avoid recreational nitrites entirely.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Réservé aux membres Pro+
Débloquer la page complète
Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Amyl nitrite et Tadalafil, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Essayez Pro+ gratuitement pendant 7 jours sur le web. Sans carte.
Autres interactions de Tadalafil
- Isosorbide dinitrate + Tadalafil Contre-indiquée
- Isosorbide mononitrate + Tadalafil Contre-indiquée
- Nitroglycerin po + Tadalafil Contre-indiquée
- Nitroglycerin rectal + Tadalafil Contre-indiquée
- Nitroglycerin sublingual + Tadalafil Contre-indiquée
- Nitroglycerin transdermal + Tadalafil Contre-indiquée
Questions fréquentes
Can I take Amyl nitrite with Tadalafil?
MediHelp rates the interaction as contraindicated. Amyl nitrite and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Amyl nitrite is a rapid, potent vasodilator, and tadalafil greatly enhances its hypotensive effect. Profound hypotension, collapse and cardiac ischemia can result, including with recreational inhaled nitrites.
How serious is the interaction between Amyl nitrite and Tadalafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; allow at least 48 hours after the last tadalafil dose before any nitrate. Advise patients to avoid recreational nitrites entirely.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Isosorbide dinitrate, Isosorbide mononitrate, Nitroglycerin po. The full list is on the Tadalafil page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
