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Interactions médicamenteuses

Anagrelide + Bedaquiline

Gravité: Majeure

Anagrelide and Bedaquiline: major interaction.

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Résumé

Bedaquiline prolongs the QTc interval and anagrelide can do the same, so combined use raises the risk of torsades de pointes. Bedaquiline labeling advises caution with other QT-prolonging drugs.

Ce que signifie cette interaction, en termes simples

Anagrelide and Bedaquiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Anagrelide belongs to Cardiovascular; Bedaquiline belongs to Anti Bacterial.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive pharmacodynamic prolongation of the QT interval.

Conduite à tenir

Avoid the combination when an alternative exists. If both are required, perform serial ECGs and correct potassium, magnesium and calcium; stop if QTc becomes markedly prolonged.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Anagrelide with Bedaquiline?

MediHelp rates the interaction as major. Anagrelide and Bedaquiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bedaquiline prolongs the QTc interval and anagrelide can do the same, so combined use raises the risk of torsades de pointes. Bedaquiline labeling advises caution with other QT-prolonging drugs.

How serious is the interaction between Anagrelide and Bedaquiline?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when an alternative exists. If both are required, perform serial ECGs and correct potassium, magnesium and calcium; stop if QTc becomes markedly prolonged.

What other medicines interact with Anagrelide?

MediHelp also lists interactions of Anagrelide with, for example, Panobinostat, Pimozide, Thioridazine. The full list is on the Anagrelide page.

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