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Interactions médicamenteuses

Amitriptyline + Bedaquiline

Gravité: Majeure

Amitriptyline and Bedaquiline: major interaction.

Dernière mise à jour

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Résumé

Both drugs can prolong the QT interval, so using them together raises the chance of clinically significant QTc prolongation and torsades de pointes. The risk is greater with electrolyte disturbances, cardiac disease or other QT-prolonging drugs.

Ce que signifie cette interaction, en termes simples

Amitriptyline and Bedaquiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Amitriptyline belongs to Central Nervous System; Bedaquiline belongs to Anti Bacterial.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive pharmacodynamic prolongation of cardiac repolarization through blockade of cardiac potassium channels.

Conduite à tenir

Obtain a baseline ECG and repeat it periodically during co-treatment, and correct potassium, magnesium and calcium abnormalities. Stop or replace amitriptyline if QTc becomes markedly prolonged.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amitriptyline with Bedaquiline?

MediHelp rates the interaction as major. Amitriptyline and Bedaquiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so using them together raises the chance of clinically significant QTc prolongation and torsades de pointes. The risk is greater with electrolyte disturbances, cardiac disease or other QT-prolonging drugs.

How serious is the interaction between Amitriptyline and Bedaquiline?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat it periodically during co-treatment, and correct potassium, magnesium and calcium abnormalities. Stop or replace amitriptyline if QTc becomes markedly prolonged.

What other medicines interact with Amitriptyline?

MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.

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