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Interactions médicamenteuses

Anagrelide + Vandetanib

Gravité: Contre-indiquée

Anagrelide and Vandetanib: contraindicated interaction.

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Résumé

Vandetanib has a boxed warning for QT prolongation, torsades de pointes and sudden death, and its labeling advises against other QT-prolonging drugs. Adding anagrelide increases this risk.

Ce que signifie cette interaction, en termes simples

Anagrelide and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Anagrelide belongs to Cardiovascular; Vandetanib belongs to Oncology.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive pharmacodynamic QT prolongation.

Conduite à tenir

Avoid the combination and choose an alternative to anagrelide while vandetanib is in use. Monitor ECG and electrolytes according to vandetanib labeling.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Anagrelide with Vandetanib?

MediHelp rates the interaction as contraindicated. Anagrelide and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vandetanib has a boxed warning for QT prolongation, torsades de pointes and sudden death, and its labeling advises against other QT-prolonging drugs. Adding anagrelide increases this risk.

How serious is the interaction between Anagrelide and Vandetanib?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative to anagrelide while vandetanib is in use. Monitor ECG and electrolytes according to vandetanib labeling.

What other medicines interact with Anagrelide?

MediHelp also lists interactions of Anagrelide with, for example, Panobinostat, Pimozide, Thioridazine. The full list is on the Anagrelide page.

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