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Interactions médicamenteuses

Anagrelide + Milrinone

Gravité: Majeure

Anagrelide and Milrinone: major interaction.

Dernière mise à jour

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Résumé

Both drugs are PDE3 inhibitors, so combined use may enhance positive inotropic, chronotropic and vasodilatory effects. This increases the risk of tachycardia, arrhythmias, hypotension and fluid retention or heart failure complications.

Ce que signifie cette interaction, en termes simples

Anagrelide and Milrinone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Anagrelide belongs to Cardiovascular; Milrinone belongs to Cardiovascular.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive phosphodiesterase 3 inhibition.

Conduite à tenir

Avoid combined use where possible; if unavoidable, monitor ECG, blood pressure and heart rate closely and consider holding anagrelide during milrinone infusion.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Anagrelide with Milrinone?

MediHelp rates the interaction as major. Anagrelide and Milrinone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are PDE3 inhibitors, so combined use may enhance positive inotropic, chronotropic and vasodilatory effects. This increases the risk of tachycardia, arrhythmias, hypotension and fluid retention or heart failure complications.

How serious is the interaction between Anagrelide and Milrinone?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use where possible; if unavoidable, monitor ECG, blood pressure and heart rate closely and consider holding anagrelide during milrinone infusion.

What other medicines interact with Milrinone?

MediHelp also lists interactions of Milrinone with, for example, Cilostazol, Enoximone, Inamrinone. The full list is on the Milrinone page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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