Interactions médicamenteuses
Inamrinone + Milrinone
Gravité: Majeure
Inamrinone and Milrinone: major interaction.
Dernière mise à jour
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Résumé
Both are phosphodiesterase-3 inhibitors with inotropic and vasodilating actions. Using them together duplicates therapy and increases the risk of hypotension, arrhythmias and, with inamrinone, thrombocytopenia.
Ce que signifie cette interaction, en termes simples
Inamrinone and Milrinone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Duplicate PDE-3 inhibition causing additive increases in cAMP, inotropy and vasodilation.
Conduite à tenir
Avoid combining the two; use a single PDE-3 inhibitor. If switching, stop the first drug before starting the other and monitor blood pressure and ECG.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Milrinone
- Anagrelide + Milrinone Majeure
- Cilostazol + Milrinone Majeure
- Enoximone + Milrinone Majeure
- Milrinone + Olprinone Majeure
- Milrinone + Riociguat Majeure
- Milrinone + Ozanimod Mineure
Questions fréquentes
Can I take Inamrinone with Milrinone?
MediHelp rates the interaction as major. Inamrinone and Milrinone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are phosphodiesterase-3 inhibitors with inotropic and vasodilating actions. Using them together duplicates therapy and increases the risk of hypotension, arrhythmias and, with inamrinone, thrombocytopenia.
How serious is the interaction between Inamrinone and Milrinone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining the two; use a single PDE-3 inhibitor. If switching, stop the first drug before starting the other and monitor blood pressure and ECG.
What other medicines interact with Milrinone?
MediHelp also lists interactions of Milrinone with, for example, Anagrelide, Cilostazol, Enoximone. The full list is on the Milrinone page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
