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Interactions médicamenteuses

Apalutamide + Cariprazine

Gravité: Majeure

Apalutamide and Cariprazine: major interaction.

Dernière mise à jour

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Résumé

Apalutamide is a strong CYP3A4 inducer and may lower exposure to cariprazine and its active metabolites, which are cleared mainly by CYP3A4. This may reduce antipsychotic efficacy.

Ce que signifie cette interaction, en termes simples

Apalutamide and Cariprazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Apalutamide belongs to Endocrine; Cariprazine belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Induction of CYP3A4 by apalutamide increases cariprazine metabolism and lowers plasma concentrations.

Conduite à tenir

Concomitant use of cariprazine with strong CYP3A4 inducers is not recommended, so choose an alternative where possible. If coadministered, monitor closely for relapse and adjust the cariprazine dose according to response.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Apalutamide with Cariprazine?

MediHelp rates the interaction as major. Apalutamide and Cariprazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide is a strong CYP3A4 inducer and may lower exposure to cariprazine and its active metabolites, which are cleared mainly by CYP3A4. This may reduce antipsychotic efficacy.

How serious is the interaction between Apalutamide and Cariprazine?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Concomitant use of cariprazine with strong CYP3A4 inducers is not recommended, so choose an alternative where possible. If coadministered, monitor closely for relapse and adjust the cariprazine dose according to response.

What other medicines interact with Cariprazine?

MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.

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