Aller au contenu
MediHelp
MediHelp Référence médicamenteuse

Interactions médicamenteuses

Apalutamide + Doravirine

Gravité: Contre-indiquée

Apalutamide and Doravirine: contraindicated interaction.

Dernière mise à jour

Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.

Le contenu clinique de cette page n'est disponible qu'en anglais.

Résumé

Apalutamide is a strong CYP3A inducer and can markedly lower doravirine plasma concentrations. This may lead to loss of virologic suppression and selection of HIV resistance.

Ce que signifie cette interaction, en termes simples

Apalutamide and Doravirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Apalutamide belongs to Endocrine; Doravirine belongs to Anti Virals.

Niveau de preuve: High

Pourquoi elle survient

Apalutamide induces CYP3A4, increasing the metabolism of doravirine, which is a CYP3A substrate.

Conduite à tenir

Do not coadminister; choose an alternative antiandrogen or antiretroviral regimen without dependence on CYP3A exposure. Allow time for enzyme induction to wane after stopping apalutamide before relying on doravirine.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Réservé aux membres Pro+

Débloquer la page complète

Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Apalutamide et Doravirine, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
Créer un compte gratuit Se connecter

Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.

Questions fréquentes

Can I take Apalutamide with Doravirine?

MediHelp rates the interaction as contraindicated. Apalutamide and Doravirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Apalutamide is a strong CYP3A inducer and can markedly lower doravirine plasma concentrations. This may lead to loss of virologic suppression and selection of HIV resistance.

How serious is the interaction between Apalutamide and Doravirine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; choose an alternative antiandrogen or antiretroviral regimen without dependence on CYP3A exposure. Allow time for enzyme induction to wane after stopping apalutamide before relying on doravirine.

What other medicines interact with Apalutamide?

MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Elbasvir / grazoprevir. The full list is on the Apalutamide page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

Télécharger surApp Store Disponible surGoogle Play

Parcourir de A à Z · Interactions médicamenteuses

Télécharger l'app Se connecter