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Interactions médicamenteuses

Apalutamide + Lenacapavir

Gravité: Contre-indiquée

Apalutamide and Lenacapavir: contraindicated interaction.

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Résumé

Strong CYP3A inducers significantly reduce lenacapavir concentrations, which may lead to loss of virologic response and resistance. Labeling contraindicates this combination.

Ce que signifie cette interaction, en termes simples

Apalutamide and Lenacapavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Apalutamide belongs to Endocrine; Lenacapavir belongs to Anti Virals.

Niveau de preuve: High

Pourquoi elle survient

Apalutamide induces CYP3A4 (and other pathways), increasing lenacapavir clearance.

Conduite à tenir

Avoid coadministration and use an alternative to apalutamide. Consider that induction persists for weeks after discontinuation.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Apalutamide with Lenacapavir?

MediHelp rates the interaction as contraindicated. Apalutamide and Lenacapavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Strong CYP3A inducers significantly reduce lenacapavir concentrations, which may lead to loss of virologic response and resistance. Labeling contraindicates this combination.

How serious is the interaction between Apalutamide and Lenacapavir?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration and use an alternative to apalutamide. Consider that induction persists for weeks after discontinuation.

What other medicines interact with Apalutamide?

MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.

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