Drug interactions
Apalutamide + Lenacapavir
Severity: Contraindicated
Apalutamide and Lenacapavir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP3A inducers significantly reduce lenacapavir concentrations, which may lead to loss of virologic response and resistance. Labeling contraindicates this combination.
What this interaction means in plain words
Apalutamide and Lenacapavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apalutamide belongs to Endocrine; Lenacapavir belongs to Anti Virals.
Why it happens
Apalutamide induces CYP3A4 (and other pathways), increasing lenacapavir clearance.
What to do
Avoid coadministration and use an alternative to apalutamide. Consider that induction persists for weeks after discontinuation.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Lenacapavir
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
- Amobarbital + Lenacapavir Major
Frequently asked questions
Can I take Apalutamide with Lenacapavir?
MediHelp rates the interaction as contraindicated. Apalutamide and Lenacapavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Strong CYP3A inducers significantly reduce lenacapavir concentrations, which may lead to loss of virologic response and resistance. Labeling contraindicates this combination.
How serious is the interaction between Apalutamide and Lenacapavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration and use an alternative to apalutamide. Consider that induction persists for weeks after discontinuation.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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