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Interactions médicamenteuses

Apalutamide + Theophylline

Gravité: Majeure

Apalutamide and Theophylline: major interaction.

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Résumé

Apalutamide is a potent enzyme inducer and can lower theophylline exposure, leading to loss of bronchodilator control. Theophylline has a narrow therapeutic window, so subtherapeutic levels may worsen asthma or COPD.

Ce que signifie cette interaction, en termes simples

Apalutamide and Theophylline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Apalutamide belongs to Endocrine; Theophylline belongs to Respiratory.

Niveau de preuve: Moderate

Pourquoi elle survient

Apalutamide induces CYP1A2 and CYP3A4, increasing theophylline metabolism.

Conduite à tenir

Monitor serum theophylline concentrations and clinical response after starting apalutamide, and increase the dose if needed. Consider an alternative bronchodilator if control is inadequate.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Apalutamide with Theophylline?

MediHelp rates the interaction as major. Apalutamide and Theophylline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide is a potent enzyme inducer and can lower theophylline exposure, leading to loss of bronchodilator control. Theophylline has a narrow therapeutic window, so subtherapeutic levels may worsen asthma or COPD.

How serious is the interaction between Apalutamide and Theophylline?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum theophylline concentrations and clinical response after starting apalutamide, and increase the dose if needed. Consider an alternative bronchodilator if control is inadequate.

What other medicines interact with Theophylline?

MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Bupropion. The full list is on the Theophylline page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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