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Interactions médicamenteuses

Cimetidine + Theophylline

Gravité: Majeure

Cimetidine and Theophylline: major interaction.

Dernière mise à jour Sources: US FDA label

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Résumé

Cimetidine reduces theophylline clearance and can substantially raise serum levels, risking nausea, tachycardia, arrhythmia and seizures. Theophylline has a narrow therapeutic index so this is clinically important.

Ce que signifie cette interaction, en termes simples

Cimetidine and Theophylline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Cimetidine belongs to Gastrointestinal Tract; Theophylline belongs to Respiratory.

Niveau de preuve: High

Pourquoi elle survient

Cimetidine inhibits CYP1A2 (and CYP3A4), decreasing theophylline metabolism.

Conduite à tenir

Prefer an alternative acid suppressant such as famotidine or a proton pump inhibitor. If combined, reduce the theophylline dose and monitor serum concentrations.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Références

Questions fréquentes

Can I take Cimetidine with Theophylline?

MediHelp rates the interaction as major. Cimetidine and Theophylline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cimetidine reduces theophylline clearance and can substantially raise serum levels, risking nausea, tachycardia, arrhythmia and seizures. Theophylline has a narrow therapeutic index so this is clinically important.

How serious is the interaction between Cimetidine and Theophylline?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative acid suppressant such as famotidine or a proton pump inhibitor. If combined, reduce the theophylline dose and monitor serum concentrations.

What other medicines interact with Theophylline?

MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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