Interactions médicamenteuses
Aprepitant + Atogepant
Gravité: Modérée
Aprepitant and Atogepant: moderate interaction.
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Résumé
Atogepant is a CYP3A4 substrate. Aprepitant inhibits CYP3A4 when given as a short course, so atogepant exposure is more likely to increase than decrease, and the legacy direction is doubtful. Higher atogepant levels may increase adverse effects such as nausea, constipation and fatigue.
Ce que signifie cette interaction, en termes simples
Aprepitant and Atogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Atogepant belongs to Central Nervous System.
Pourquoi elle survient
Aprepitant inhibits CYP3A4, reducing atogepant metabolism, although aprepitant can also induce CYP3A4 with longer exposure.
Conduite à tenir
Monitor for atogepant adverse effects during aprepitant courses. Consider dose limitation of atogepant in line with labeling for CYP3A4 inhibitors.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Aprepitant
- Aprepitant + Lomitapide Contre-indiquée
- Aprepitant + Pimozide Contre-indiquée
- Aprepitant + Avapritinib Majeure
- Aprepitant + Bosutinib Majeure
- Aprepitant + Carbamazepine Majeure
- Aprepitant + Cobicistat Majeure
Autres interactions de Atogepant
- Amobarbital + Atogepant Modérée
- Apalutamide + Atogepant Modérée
- Armodafinil + Atogepant Modérée
- Atogepant + Bosentan Modérée
- Atogepant + Carbamazepine Modérée
- Atogepant + Chloramphenicol Modérée
Questions fréquentes
Can I take Aprepitant with Atogepant?
MediHelp rates the interaction as moderate. Aprepitant and Atogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atogepant is a CYP3A4 substrate. Aprepitant inhibits CYP3A4 when given as a short course, so atogepant exposure is more likely to increase than decrease, and the legacy direction is doubtful. Higher atogepant levels may increase adverse effects such as nausea, constipation and fatigue.
How serious is the interaction between Aprepitant and Atogepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for atogepant adverse effects during aprepitant courses. Consider dose limitation of atogepant in line with labeling for CYP3A4 inhibitors.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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