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Interactions médicamenteuses

Arsenic trioxide + Quinine

Gravité: Contre-indiquée

Arsenic trioxide and Quinine: contraindicated interaction.

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Résumé

Arsenic trioxide causes marked QT prolongation and torsades de pointes, and quinine adds to this effect. The combination may result in life-threatening arrhythmias.

Ce que signifie cette interaction, en termes simples

Arsenic trioxide and Quinine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Arsenic trioxide belongs to Oncology; Quinine belongs to Anti Parasitic.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive pharmacodynamic QT prolongation through cardiac potassium channel effects.

Conduite à tenir

Avoid the combination; use a non-QT-prolonging antimalarial or cramp treatment during arsenic trioxide therapy. If quinine is essential for severe malaria, monitor ECG continuously and keep electrolytes corrected.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Arsenic trioxide with Quinine?

MediHelp rates the interaction as contraindicated. Arsenic trioxide and Quinine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Arsenic trioxide causes marked QT prolongation and torsades de pointes, and quinine adds to this effect. The combination may result in life-threatening arrhythmias.

How serious is the interaction between Arsenic trioxide and Quinine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use a non-QT-prolonging antimalarial or cramp treatment during arsenic trioxide therapy. If quinine is essential for severe malaria, monitor ECG continuously and keep electrolytes corrected.

What other medicines interact with Quinine?

MediHelp also lists interactions of Quinine with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Quinine page.

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