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Interactions médicamenteuses

Dofetilide + Quinine

Gravité: Contre-indiquée

Dofetilide and Quinine: contraindicated interaction.

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Résumé

Both drugs prolong the QT interval, and quinine may also reduce dofetilide renal elimination by competing for cationic tubular secretion. This raises dofetilide levels and the risk of torsades de pointes, a potentially fatal arrhythmia.

Ce que signifie cette interaction, en termes simples

Dofetilide and Quinine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Dofetilide belongs to Cardiovascular; Quinine belongs to Anti Parasitic.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive QT prolongation combined with competition for renal tubular cationic secretion that increases dofetilide exposure.

Conduite à tenir

Avoid concurrent use and choose a non-QT-prolonging antimalarial or alternative antiarrhythmic. If quinine is essential, hold dofetilide and use continuous ECG monitoring.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Dofetilide with Quinine?

MediHelp rates the interaction as contraindicated. Dofetilide and Quinine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and quinine may also reduce dofetilide renal elimination by competing for cationic tubular secretion. This raises dofetilide levels and the risk of torsades de pointes, a potentially fatal arrhythmia.

How serious is the interaction between Dofetilide and Quinine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose a non-QT-prolonging antimalarial or alternative antiarrhythmic. If quinine is essential, hold dofetilide and use continuous ECG monitoring.

What other medicines interact with Quinine?

MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Quinine page.

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