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Interactions médicamenteuses

Nilotinib + Quinine

Gravité: Contre-indiquée

Nilotinib and Quinine: contraindicated interaction.

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Résumé

Nilotinib carries a boxed warning for QT prolongation and sudden death, and quinine adds further QT-prolonging effect. Quinine may also raise nilotinib levels through CYP3A4 inhibition, which compounds the risk.

Ce que signifie cette interaction, en termes simples

Nilotinib and Quinine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Nilotinib belongs to Oncology; Quinine belongs to Anti Parasitic.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive hERG-mediated QT prolongation, with possible CYP3A4 inhibition by quinine increasing nilotinib exposure.

Conduite à tenir

Do not use together; choose an alternative antimalarial or defer nilotinib if quinine is essential. If unavoidable, use continuous ECG monitoring and electrolyte correction.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Nilotinib with Quinine?

MediHelp rates the interaction as contraindicated. Nilotinib and Quinine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nilotinib carries a boxed warning for QT prolongation and sudden death, and quinine adds further QT-prolonging effect. Quinine may also raise nilotinib levels through CYP3A4 inhibition, which compounds the risk.

How serious is the interaction between Nilotinib and Quinine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose an alternative antimalarial or defer nilotinib if quinine is essential. If unavoidable, use continuous ECG monitoring and electrolyte correction.

What other medicines interact with Quinine?

MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.

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