Interactions médicamenteuses
Artemether / lumefantrine + Oxcarbazepine
Gravité: Majeure
Artemether / lumefantrine and Oxcarbazepine: major interaction.
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Résumé
Oxcarbazepine is a weaker CYP3A4 inducer than carbamazepine but may still lower artemether and lumefantrine levels, risking malaria treatment failure.
Ce que signifie cette interaction, en termes simples
Artemether / lumefantrine and Oxcarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Oxcarbazepine's active metabolite induces CYP3A4, increasing clearance of artemether and lumefantrine.
Conduite à tenir
Prefer an alternative antimalarial or anticonvulsant; if combined, monitor for treatment failure and follow up parasitemia.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contre-indiquée
- Oxcarbazepine + Rilpivirine Contre-indiquée
- Atazanavir + Oxcarbazepine Majeure
- Benzhydrocodone / acetaminophen + Oxcarbazepine Majeure
- Bictegravir + Oxcarbazepine Majeure
- Bosutinib + Oxcarbazepine Majeure
Questions fréquentes
Can I take Artemether / lumefantrine with Oxcarbazepine?
MediHelp rates the interaction as major. Artemether / lumefantrine and Oxcarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxcarbazepine is a weaker CYP3A4 inducer than carbamazepine but may still lower artemether and lumefantrine levels, risking malaria treatment failure.
How serious is the interaction between Artemether / lumefantrine and Oxcarbazepine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antimalarial or anticonvulsant; if combined, monitor for treatment failure and follow up parasitemia.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Atazanavir. The full list is on the Oxcarbazepine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
