Interactions médicamenteuses
Cabotegravir + Oxcarbazepine
Gravité: Contre-indiquée
Cabotegravir and Oxcarbazepine: contraindicated interaction.
Dernière mise à jour
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
Résumé
Oxcarbazepine may significantly lower cabotegravir concentrations, particularly with long-acting injectable therapy. This can cause loss of viral suppression and integrase resistance.
Ce que signifie cette interaction, en termes simples
Cabotegravir and Oxcarbazepine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cabotegravir belongs to Anti Virals; Oxcarbazepine belongs to Central Nervous System.
Pourquoi elle survient
Oxcarbazepine induces UGT1A1 (and possibly UGT1A9), increasing cabotegravir glucuronidation.
Conduite à tenir
Do not coadminister; use a non-inducing antiseizure drug such as levetiracetam if possible. Otherwise select a different antiretroviral regimen.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Réservé aux membres Pro+
Débloquer la page complète
Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Cabotegravir et Oxcarbazepine, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.
Autres interactions de Cabotegravir
- Apalutamide + Cabotegravir Contre-indiquée
- Cabotegravir + Carbamazepine Contre-indiquée
- Cabotegravir + Phenobarbitone Contre-indiquée
- Cabotegravir + Phenytoin Contre-indiquée
- Cabotegravir + Rifabutin Contre-indiquée
- Cabotegravir + Rifampicin Contre-indiquée
Autres interactions de Oxcarbazepine
- Oxcarbazepine + Rilpivirine Contre-indiquée
- Artemether / lumefantrine + Oxcarbazepine Majeure
- Atazanavir + Oxcarbazepine Majeure
- Benzhydrocodone / acetaminophen + Oxcarbazepine Majeure
- Bictegravir + Oxcarbazepine Majeure
- Bosutinib + Oxcarbazepine Majeure
Questions fréquentes
Can I take Cabotegravir with Oxcarbazepine?
MediHelp rates the interaction as contraindicated. Cabotegravir and Oxcarbazepine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Oxcarbazepine may significantly lower cabotegravir concentrations, particularly with long-acting injectable therapy. This can cause loss of viral suppression and integrase resistance.
How serious is the interaction between Cabotegravir and Oxcarbazepine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use a non-inducing antiseizure drug such as levetiracetam if possible. Otherwise select a different antiretroviral regimen.
What other medicines interact with Cabotegravir?
MediHelp also lists interactions of Cabotegravir with, for example, Apalutamide, Carbamazepine, Phenobarbitone. The full list is on the Cabotegravir page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
