Interactions médicamenteuses
Atazanavir + Tofacitinib
Gravité: Majeure
Atazanavir and Tofacitinib: major interaction.
Dernière mise à jour
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Résumé
Atazanavir inhibits CYP3A4 and raises tofacitinib exposure, increasing the risk of dose-related adverse effects such as infection, cytopenias and lipid elevations. Labeling recommends reducing the tofacitinib dose with strong CYP3A4 inhibitors.
Ce que signifie cette interaction, en termes simples
Atazanavir and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Tofacitinib belongs to Musculoskeletal.
Pourquoi elle survient
Strong CYP3A4 inhibition by ritonavir-boosted or unboosted atazanavir reduces tofacitinib clearance.
Conduite à tenir
Reduce tofacitinib to the labeled lower dose, for example once daily when the usual dose is twice daily. Monitor for infection and cytopenias.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Tofacitinib
- Baricitinib + Tofacitinib Contre-indiquée
- Cladribine + Tofacitinib Contre-indiquée
- Tofacitinib + Upadacitinib Contre-indiquée
- Abatacept + Tofacitinib Majeure
- Anti-thymocyte + Tofacitinib Majeure
- Antithymocyte globulin equine + Tofacitinib Majeure
Autres interactions de Atazanavir
- Alfuzosin + Atazanavir Contre-indiquée
- Atazanavir + Avanafil Contre-indiquée
- Atazanavir + Dronedarone Contre-indiquée
- Atazanavir + Eletriptan Contre-indiquée
- Atazanavir + Eplerenone Contre-indiquée
- Atazanavir + Ergotamine Contre-indiquée
Questions fréquentes
Can I take Atazanavir with Tofacitinib?
MediHelp rates the interaction as major. Atazanavir and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir inhibits CYP3A4 and raises tofacitinib exposure, increasing the risk of dose-related adverse effects such as infection, cytopenias and lipid elevations. Labeling recommends reducing the tofacitinib dose with strong CYP3A4 inhibitors.
How serious is the interaction between Atazanavir and Tofacitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce tofacitinib to the labeled lower dose, for example once daily when the usual dose is twice daily. Monitor for infection and cytopenias.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
