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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Anti-thymocyte + Tofacitinib

Gravité: Majeure

Anti-thymocyte and Tofacitinib: major interaction.

Dernière mise à jour

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Résumé

Tofacitinib is a Janus kinase inhibitor that impairs cytokine signalling, and anti-thymocyte globulin depletes T cells. Combined use markedly increases the risk of serious opportunistic and other infections.

Ce que signifie cette interaction, en termes simples

Anti-thymocyte and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Anti-thymocyte belongs to Miscellaneous; Tofacitinib belongs to Musculoskeletal.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive immunosuppression through T-cell depletion and JAK inhibition.

Conduite à tenir

Avoid combining where possible; the label advises against use of tofacitinib with potent immunosuppressants. If combined, monitor closely for infection and use appropriate prophylaxis.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Anti-thymocyte with Tofacitinib?

MediHelp rates the interaction as major. Anti-thymocyte and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tofacitinib is a Janus kinase inhibitor that impairs cytokine signalling, and anti-thymocyte globulin depletes T cells. Combined use markedly increases the risk of serious opportunistic and other infections.

How serious is the interaction between Anti-thymocyte and Tofacitinib?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; the label advises against use of tofacitinib with potent immunosuppressants. If combined, monitor closely for infection and use appropriate prophylaxis.

What other medicines interact with Anti-thymocyte?

MediHelp also lists interactions of Anti-thymocyte with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Anti-thymocyte page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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