Interactions médicamenteuses
Atenolol-chlorthalidone + Epinephrine
Gravité: Majeure
Atenolol-chlorthalidone and Epinephrine: major interaction.
Dernière mise à jour Sources: US FDA label
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Résumé
Atenolol blocks the beta effects of epinephrine, leaving alpha-mediated vasoconstriction unopposed, which can cause marked hypertension with reflex bradycardia. Beta-blockers may also reduce the effectiveness of epinephrine in anaphylaxis. Chlorthalidone-induced hypokalemia may add to arrhythmia risk.
Ce que signifie cette interaction, en termes simples
Atenolol-chlorthalidone and Epinephrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atenolol-chlorthalidone belongs to Cardiovascular; Epinephrine belongs to Endocrine.
Pourquoi elle survient
Beta-1 blockade by atenolol antagonizes epinephrine's cardiac and bronchodilator effects while unopposed alpha stimulation increases vascular resistance.
Conduite à tenir
Monitor blood pressure and heart rate when epinephrine is given. In anaphylaxis unresponsive to epinephrine in a beta-blocked patient, consider glucagon.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Références
Autres interactions de Atenolol-chlorthalidone
Autres interactions de Epinephrine
- Epinephrine + Isocarboxazid Contre-indiquée
- Epinephrine + Phenelzine Contre-indiquée
- Epinephrine + Tranylcypromine Contre-indiquée
- Acebutolol + Epinephrine Majeure
- Amitriptyline + Epinephrine Majeure
- Amoxapine + Epinephrine Majeure
Questions fréquentes
Can I take Atenolol-chlorthalidone with Epinephrine?
MediHelp rates the interaction as major. Atenolol-chlorthalidone and Epinephrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atenolol blocks the beta effects of epinephrine, leaving alpha-mediated vasoconstriction unopposed, which can cause marked hypertension with reflex bradycardia. Beta-blockers may also reduce the effectiveness of epinephrine in anaphylaxis. Chlorthalidone-induced hypokalemia may add to arrhythmia risk.
How serious is the interaction between Atenolol-chlorthalidone and Epinephrine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when epinephrine is given. In anaphylaxis unresponsive to epinephrine in a beta-blocked patient, consider glucagon.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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